Since the feline MDR1 mutation was more recently discovered than the canine MDR1 mutation there has been less research on the topic. The WSU PrIMe® research team is working to determine if other drugs commonly used for treating cats are substrates for feline P-glycoprotein (i.e., have the potential to cause toxicity in cats with the MDR1 mutation).
| Drug (Active Ingredient) | Brand Name | Recommendation |
|---|---|---|
| Chemotherapy | Contact MDR1Caddie™ for dosing recommendations. | |
| Emodepside | Profender | Do not use in cats with the MDR1 mutation. |
| Eprinomectin | Nexgard Combo | Do not use in cats with the MDR1 mutation. |
| Ivermectin | Heartgard | If used in accordance with label, the dose of ivermectin is low enough to be safe for cats with the MDR1 mutation. For other formulations of ivermectin contact MDR1Caddie™ for dosing recommendations |
| Loperamide | Imodium | At doses used to treat diarrhea, this drug will be expected to cause neurological toxicity in cats with the MDR1 mutation. We recommend avoiding loperamide in cats with the MDR1 mutation. |
| Milbemycin | Interceptor | If used in accordance with label, the dose of milbemycin is low enough to be safe for cats with the MDR1 mutation. For other formulations of milbemycin contact MDR1Caddie™ for dosing recommendations. |
| Moxidectin | Advantage Multi, Bravecto Plus | Oral ingestion of this topical product would be expected to cause neurological toxicity in cats with the MDR1 mutation. |
| Vinblastine | See Chemotherapy | |
| Vincristine | See Chemotherapy | |
| Vinorelbine | See Chemotherapy | |
| Selamectin | Revolution Plus | Oral ingestion of this topical product would be expected to cause neurological toxicity in cats with the MDR1 mutation. |