PrIMe Publications


Malkawi M, Woolcock AD, Lee PM, Court MH, Moore GE, Hogan DF. Comparison of metabolomics and platelet aggregometry between Plavix and generic clopidogrel in cats: a pilot study. J Feline Med Surg. 2018 Nov 14:1098612X18810887. doi: 10.1177/1098612X18810887. [Epub ahead of print] PMID: 30427274.

Haines JM, Lee PM, Hegedus RM, Hwang JK, Court MH. Investigation into the causes of aspirin resistance in healthy dogs. J Vet Pharmacol Ther. 2019 Mar;42(2):160-170. doi: 10.1111/jvp.12725. Epub 2018 Oct 9. PMID: 30302763.

Kolchanova S, Kliver S, Komissarov A, Dobrinin P, Tamazian G, Grigorev K, Wolfsberger WW, Majeske AJ, Velez-Valentin J, Valentin de la Rosa R, Paul-Murphy JR, Guzman DS, Court MH, Rodriguez-Flores JL, Martínez-Cruzado JC, Oleksyk TK. Genomes of Three Closely Related Caribbean Amazons Provide Insight for Species History and Conservation. Genes (Basel). 2019 Jan 16;10(1). pii: E54. doi: 10.3390/genes10010054. PMID: 30654561.

Perez Jimenez TE, Kukanich B, Joo H, Mealey KL, Grubb TL, Greene SA, Court MH. Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs. Drug Metab Dispos. 2019 Jan;47(1):15-25. doi: 10.1124/dmd.118.083444. Epub 2018 Oct 26. PMID: 30366901.

Lee PM, Faus MCL, Court MH. High interindividual variability in plasma clopidogrel active metabolite concentrations in healthy cats is associated with sex and cytochrome P450 2C genetic polymorphism.  J Vet Pharmacol Ther. 2019 Jan;42(1):16-25. doi: 10.1111/jvp.12717. Epub 2018 Sep 24. PMID: 30251376.


Kwara A, Yang H, Antwi S, Enimil A, Gillani FS, Dompreh A, Ortsin A, Opoku T, Bosomtwe D, Sarfo A, Wiesner L, Norman J, Alghamdi WA, Langaee T, Peloquin CA, Court MH, Greenblatt DJ. Effect of Rifampin-Isoniazid-Containing Antituberculosis Therapy on Efavirenz Pharmacokinetics in HIV-Infected Children 3 to 14 Years Old. Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01657-18. doi: 10.1128/AAC.01657-18. Print 2019 Jan. PMID: 30397066.

Perez Jimenez TE, Mealey KL, Schnider D, Grubb TL, Greene SA, Court MH. Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes.  J Vet Pharmacol Ther. 2018 Dec;41(6):815-824. doi: 10.1111/jvp.12706. Epub 2018 Aug 16. PMID: 30113702.

Slovak JE, Rivera-Velez SM, Hwang JK, Villarino NF.  Pharmacokinetics and pharmacodynamics of mycophenolic acid in healthy cats after twice-daily intravenous infusion of mycophenolate mofetil for three days.  Am J Vet Res. 2018 Oct;79(10):1093-1099. doi: 10.2460/ajvr.79.10.1093.  PMID:     30256137

Morassi A, Rivera-Vélez SM, Slovak JE, Court MH, Villarino NF.  Ex vivo binding of the immunosuppressant mycophenolic acid to dog and cat plasma proteins and the effect of co-incubated dexamethasone and prednisolone.  J Vet Pharmacol Ther. 2018 Aug;41(4):513-521. doi: 10.1111/jvp.12507. Epub 2018 Apr 23. PMID: 29687456.

Martinez MN, Court MH, Fink-Gremmels J, Mealey KL.  Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.  J Vet Pharmacol Ther. 2018 Aug;41(4):E57-E67. doi: 10.1111/jvp.12670. Epub 2018 Jun 19. Review.  PMID:     29917248

Morassi A, Rivera-Vélez SM, Slovak JE, Court MH, Villarino NF.  Ex vivo binding of the immunosuppressant mycophenolic acid to dog and cat plasma proteins and the effect of co-incubated dexamethasone and prednisolone.  J Vet Pharmacol Ther. 2018 Aug;41(4):513-521. doi: 10.1111/jvp.12507. Epub 2018 Apr 23.  PMID:     29687456

Rivera-Vélez SM, Villarino NF.  Feline urine metabolomic signature: characterization of low-molecular-weight substances in urine from domestic cats.  J Feline Med Surg. 2018 Feb;20(2):155-163. doi: 10.1177/1098612X17701010. Epub 2017 Apr 3.  PMID:     28367722

Slovak JE, Villarino NF.  Safety of oral and intravenous mycophenolate mofetil in healthy cats.  J Feline Med Surg. 2018 Feb;20(2):184-188. doi: 10.1177/1098612X17693521. Epub 2017 Feb 16.  PMID:     28206810

Dompreh A, Tang X, Zhou J, Yang H, Topletz A, Adu Ahwireng E, Antwi S, Enimil A, Langaee T, Peloquin CA, Court MH, Kwara A.  Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis.  Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02099-17. doi: 10.1128/AAC.02099-17. Print 2018 Mar.  PMID:     29263072


Rivera SM, Slovak JE, Court MH, Villarino NF. Simultaneous determination of mycophenolic acid and its glucuronide and glycoside derivatives in canine and feline plasma by UHPLC-UV. Biomed Chromatogr. 2017 Aug;31(8). doi: 10.1002/bmc.3942. Epub 2017 Feb 27. PMID: 28146301

Slovak JE, Rivera SM, Hwang JK, Court MH, Villarino NF. Pharmacokinetics of mycophenolic acid after intravenous administration of mycophenolate mofetil to healthy cats. J Vet Intern Med. 2017 Nov;31(6):1827-1832.  PMID: 28892209

Papageorgiou I, Court MH. Identification and validation of the microRNA response elements in the 3'-untranslated region of the UDP glucuronosyltransferase (UGT) 2B7 and 2B15 genes by a functional genomics approach. Biochem Pharmacol. 2017 Dec 15;146:199-213.  PMID: 28962835

Haines JM, Lee PM, Hegedus RM, Hwang JK, Court MH.  Establishment of reference ranges and evaluation of in vitro concentration-dependent platelet inhibition by acetylsalicylic acid for multiple electrode impedance aggregometry in healthy dogs.  J Vet Pharmacol Ther. 2017 Dec;40(6):618-628. PMID: 28387027

Guzman DS, Court MH, Zhu Z, Summa N, Paul-Murphy JR. Pharmacokinetics of a sustained-release formulation of meloxicam after subcutaneous administration to Hispaniolan Amazon parrots (Amazona ventralis). J Avian Med Surg. 2017 Sep;31(3):219-224. PMID: 28891702

Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ. Race, gender, and genetic polymorphism contribute to variability in acetaminophen pharmacokinetics, metabolism, and protein-adduct concentrations in healthy African-American and European-American volunteers. J Pharmacol Exp Ther. 2017 Sep;362(3):431-440. PMID: 28663312

Papageorgiou I, Court MH. Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach. Biochem Pharmacol. 2017 Aug 1; 137:93-106. PMID: 28433553

Lyngby JG, Court MH, Lee PM. Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma. J Vet Cardiol. 2017 Aug;19(4):384-395. PMID: 28602635

Lewis RS, Fidel J, Dassanayake S, Court MH, Burke NS, Mealey KL. Comparison of chemotherapeutic drug resistance in cells transfected with canine ABCG2 or feline ABCG2. Vet Comp Oncol. 2017 Jun;15(2):411-420. PMID:26464002

Slovak JE, Mealey K, Court MH. Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes. J Vet Pharmacol Ther. 2017 Apr;40(2):123-129. PMID: 27301298

Perez TE, Mealey KL, Burke NS, Grubb TL, Court MH, Greene SA.  Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs.  Vet Anaesth Analg. 2017 Mar;44(2):370-374. PMID: 28214221

Court MH, Robbins AH, Whitford AM, Beck EV, Tseng FS, Reeder DM. Pharmacokinetics of terbinafine in little brown myotis (Myotis lucifugus) infected with Pseudogymnoascus destructans. Am J Vet Res. 2017 Jan;78(1):90-99. PMID: 28029293

Street CM, Zhu Z, Finel M, Court MH. Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms. Xenobiotica. 2017 Jan;47(1):1-10. PMID: 26999266

Mealey KL, Dassanayake S, Burke NS.  Establishment of a cell line for assessing drugs as canine P-glycoprotein substrates: proof of principle.  J Vet Pharmacol Ther. 2017 Oct;40(5):545-551. doi: 10.1111/jvp.12390. Epub 2017 Jan 17.  PMID:     28093773


Perez Jimenez TE, Mealey KL, Grubb TL, Greene SA, Court MH. Tramadol metabolism to O-desmethyl tramadol (M1) and N-desmethyl tramadol (M2) by dog liver microsomes: Species comparison and identification of responsible canine cytochrome P-450s (CYPs). Drug Metab Dispos. 2016 Oct 6; 44 (12) 1963-1972. PMID: 27758804

Rivera Vélez SM., Morassi A., Court MH., Slovak JE, Villarino NF. Development and validation of an ultrafast chromatographic method for quantification of the immunosuppressant mycophenolic acid in canine, feline and human plasma. J Pharm Biomed Anal. 2016 Aug 12;131:94-102

Papageorgiou I, Freytsis M, Court MH. Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver. Biochem Pharmacol. 2016 Oct 1;117:78-87. PMID: 27531059

Redmon JM, Shrestha B, Cerundolo R, Court MH. Soy isoflavone metabolism in cats compared with other species: urinary metabolite concentrations and glucuronidation by liver microsomes. Xenobiotica. 2016 May;46(5):406-15

Gammal RS, Court MH, Haidar CE, Iwuchukwu OF, Gaur AH, Alvarellos M, Guillemette C, Lennox JL, Whirl-Carrillo M, Brummel SS, Ratain MJ, Klein TE, Schackman BR, Caudle KE, Haas DW; Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing. Clin Pharmacol Ther. 2016 Apr;99(4):363-9

Costa A, Sellon RK, Court M, Burke NS, Mealey KL. Polymorphisms in the canine glucocorticoid receptor alpha gene (NR3C1α). J Vet Pharmacol Ther. 2016 Feb;39(1):16-21


Chen S, Laverdiere I, Tourancheau A, Jonker D, Couture F, Cecchin E, Villeneuve L, Harvey M, Court MH, Innocenti F, Toffoli G, Lévesque E, Guillemette C. A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients. Pharmacogenomics J. 2015 Dec;15(6):513-20. doi: 10.1038/tpj.2015.12. Epub 2015 Mar 17.

Mealey KL, Burke NS. Identification of a nonsense mutation in feline ABCB1. J Vet Pharmacol Ther. 2015 Oct;38(5):429-33.

Mealey KL, Fidel J. P-glycoprotein mediated drug interactions in animals and humans with cancer. J Vet Intern Med 2015 Jan;29(1):1-6.


Mealey KL, Dassanayake S, Burke NS. Tyrosine kinase inhibitors enhance ciprofloxacin-induced phototoxicity by inhibiting ABCG2. Oncology 2014;87(6):364-70.

Court MH, Almutairi FE, Greenblatt DJ, Hazarika S, Sheng H, Klein K, Zanger UM, Bourgea J, Patten CJ, Kwara A. Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6. Antimicrob Agents Chemother. 2014 Jul;58(7):4145-52. doi: 10.1128/AAC.02532-14. Epub 2014 May 12.