PrIMe Publications


Role of an ABCB11930_1931del TC gene mutation in a temporal cluster of macrocyclic lactone-induced neurologic toxicosis in cats associated with products labeled for companion animal use.  Mealey KL, Burke NS, Connors RL. J Am Vet Med Assoc. 2021 Jul 1;259(1):72-76. PMID: 34125616

Tolerance and Pharmacokinetics of Galliprant™ Administered Orally to Collies Homozygous for MDR1-1Δ. Heit MC, Mealey KL, King SB.  J Vet Pharmacol Ther. 2021 Jul 4. Epub ahead of print. PMID: 34219249.

A genetic polymorphism in P2RY1 impacts response to clopidogrel in cats with hypertrophic cardiomyopathy. Ueda Y, Li RHL, Nguyen N, Ontiveros ES, Kovacs SL, Oldach MS, Vernau KM, Court MH, Stern JA. Sci Rep. 2021 Jun 15;11(1):12522. PMID: 341311673.

Applying metabolomics to veterinary pharmacology and therapeutics. Rivera-Velez SM, Navas J, Villarino NF.  J Vet Pharmacol Ther. 2021 Mar 14. Epub ahead of print. PMID: 33719079.

PREVALENCE OF THE ABCB1-1Δ GENE IN NONDOMESTIC SPECIES OF THE CANIDAE FAMILY. Stafford EG, Harrison T, Kortum A, Mealey KL.  J Zoo Wildl Med. 2021 Jan;51(4):1007-1011. PMID: 33480582.

Canine orosomucoid (alpha-1 acid glycoprotein) variants and their influence on drug plasma protein binding. Costa AP, Court MH, Villarino NF, Burke NS, Mealey KL. J Vet Pharmacol Ther. 2021 Jan;44(1):116-125. PMID: 32744755.


Pharmacometabolomics with a combination of PLS-DA and random forest algorithm analyses reveal meloxicam alters feline plasma metabolite profiles. Broughton-Neiswanger LE, Rivera-Velez SM, Suarez MA, Slovak JE, Hwang JK, Villarino NF.  J Vet Pharmacol Ther. 2020 Nov;43(6):591-601. PMID: 32562314.

Plasmodium Impairs Antibacterial Innate Immunity to Systemic Infections in Part Through Hemozoin-Bound Bioactive Molecules. Harding CL, Villarino NF, Valente E, Schwarzer E, Schmidt NW. Front Cell Infect Microbiol. 2020 Jun 30;10:328. PMID: 32714882.

Development of prednisone resistance in naïve canine lymphoma: Longitudinal evaluation of NR3C1α, ABCB1, and 11β-HSD mRNA expression. Hanot CC, Mealey KL, Fidel JL, Burke NS, White LA, Sellon RK.  J Vet Pharmacol Ther. 2020 Mar;43(2):231-236. PMID: 31943234

Plasma disposition of gabapentin after the intragastric administration of escalating doses to adult horses.  Gold JR, Grubb TL, Green S, Cox S, Villarino NF. J Vet Intern Med. 2020 Mar;34(2):933-940. PMID: 32034928

Can blood serum amyloid A concentrations in horses differentiate synovial sepsis from extrasynovial inflammation and determine response to treatment?  Sinovich M, Villarino NF, Singer E, Robinson CS, Rubio-Martínez LM. Vet Rec. 2020 Sep 19;187(6):235. PMID: 32098906.

Urinary chemical fingerprint left behind by repeated NSAID administration: Discovery of putative biomarkers using artificial intelligence. Broughton-Neiswanger LE, Rivera-Velez SM, Suarez MA, Slovak JE, Piñeyro PE, Hwang JK, Villarino NF. PLoS One. 2020 Feb 13;15(2):e0228989. PMID: 32053695

Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization.  Martinez SE, Andresen MC, Zhu Z, Papageorgiou I, Court MH. Sci Rep. 2020 Jan 9;10(1):69. PMID: 31919457.


Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability.  Martinez SE, Shi J, Zhu HJ, Perez Jimenez TE, Zhu Z, Court MH.  Drug Metab Dispos. 2019 Nov;47(11):1314-1324. PMID: 31427433

Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding.  Costa AP, Court MH, Burke NS, Zhu Z, Mealey KL, Villarino NF.  Drug Metab Dispos. 2019 Oct;47(10):1024-1031. PMID: 31481400

The lipidome of Thoroughbred racehorses before and after supramaximal exercise. Nolazco Sassot L, Villarino NF, Dasgupta N, Morrison JJ, Bayly WM, Gang D, Sanz MG.  Equine Vet J. 2019 Sep;51(5):696-700. doi: 10.1111/evj.13064. Epub 2019 Feb 9.  PMID:  30600546

Pharmacokinetics of mycophenolic acid and its effect on CD4+ and CD8+ T cells after oral administration of mycophenolate mofetil to healthy cats.
Slovak JE, Hwang JK, Rivera SM, Villarino NF.  J Vet Intern Med. 2019 Sep;33(5):2020-2028. doi: 10.1111/jvim.15585. Epub 2019 Aug 19. PMID:  31423655

Comparison of metabolomics and platelet aggregometry between Plavix and generic clopidogrel in cats: a pilot study.Malkawi M, Woolcock AD, Lee PM, Court MH, Moore GE, Hogan DF.  J Feline Med Surg. 2019 Oct;21(10):951-958. PMID: 30427274.

Pharmacokinetics of furosemide in thoroughbred horses subjected to supramaximal treadmill exercise with and without controlled access to water.  Villarino NF, Lopez CM, Sams RA, Bayly WM. BMC Vet Res. 2019 Aug 2;15(1):275. doi: 10.1186/s12917-019-2017-3. PMID:   31375096

Understanding the effect of repeated administration of meloxicam on feline renal cortex and medulla: A lipidomics and metabolomics approach.
Rivera-Velez SM, Broughton-Neiswanger LE, Suarez MA, Slovak JE, Hwang JK, Navas J, Leung AWS, Piñeyro PE, Villarino NF.  J Vet Pharmacol Ther. 2019 Jul;42(4):476-486. doi: 10.1111/jvp.12788. Epub 2019 Jun 12. PMID:   31190341

Personalized medicine: going to the dogs?  Mealey KL, Martinez SE, Villarino NF, Court MH. Hum Genet. 2019 May;138(5):467-481. PMID: 31032534

Repeated administration of the NSAID meloxicam alters the plasma and urine lipidome.  Rivera-Velez SM, Broughton-Neiswanger LE, Suarez M, Piñeyro P, Navas J, Chen S, Hwang J, Villarino NF. Sci Rep. 2019 Mar 13;9(1):4303. PMID:   30867479

Investigation into the causes of aspirin resistance in healthy dogs. Haines JM, Lee PM, Hegedus RM, Hwang JK, Court MH. J Vet Pharmacol Ther. 2019 Mar;42(2):160-170. PMID: 30302763.

Identification of differences in the formation of plasma glycated proteins between dogs and humans under diabetes-like glucose concentration conditions.
Rivera-Velez SM, Hwang J, Navas J, Villarino NF.  Int J Biol Macromol. 2019 Feb 15;123:1197-1203. PMID:   30465839

Genomes of Three Closely Related Caribbean Amazons Provide Insight for Species History and Conservation. Kolchanova S, Kliver S, Komissarov A, Dobrinin P, Tamazian G, Grigorev K, Wolfsberger WW, Majeske AJ, Velez-Valentin J, Valentin de la Rosa R, Paul-Murphy JR, Guzman DS, Court MH, Rodriguez-Flores JL, Martínez-Cruzado JC, Oleksyk TK. Genes (Basel). 2019 Jan 16;10(1). pii: E54. PMID: 30654561.

Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs. Perez Jimenez TE, Kukanich B, Joo H, Mealey KL, Grubb TL, Greene SA, Court MH. Drug Metab Dispos. 2019 Jan;47(1):15-25. PMID: 30366901.

High interindividual variability in plasma clopidogrel active metabolite concentrations in healthy cats is associated with sex and cytochrome P450 2C genetic polymorphism.
Lee PM, Faus MCL, Court MH.  J Vet Pharmacol Ther. 2019 Jan;42(1):16-25. PMID: 30251376.

Evaluation of Transdermal Administration of Phenobarbital in Healthy Cats. Krull DP, Thomovsky SA, Chen AV, Mealey KL, Papich MG. J Am Anim Hosp Assoc. 2019 Jan/Feb;55(1):1-7. PMID: 30427717


Effect of Rifampin-Isoniazid-Containing Antituberculosis Therapy on Efavirenz Pharmacokinetics in HIV-Infected Children 3 to 14 Years Old. Kwara A, Yang H, Antwi S, Enimil A, Gillani FS, Dompreh A, Ortsin A, Opoku T, Bosomtwe D, Sarfo A, Wiesner L, Norman J, Alghamdi WA, Langaee T, Peloquin CA, Court MH, Greenblatt DJ. Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01657-18. PMID: 30397066.

Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes.  Perez Jimenez TE, Mealey KL, Schnider D, Grubb TL, Greene SA, Court MH. J Vet Pharmacol Ther. 2018 Dec;41(6):815-824. PMID: 30113702.

Pharmacokinetics and pharmacodynamics of mycophenolic acid in healthy cats after twice-daily intravenous infusion of mycophenolate mofetil for three days.  Slovak JE, Rivera-Velez SM, Hwang JK, Villarino NF.  Am J Vet Res. 2018 Oct;79(10):1093-1099. PMID:     30256137

Ex vivo binding of the immunosuppressant mycophenolic acid to dog and cat plasma proteins and the effect of co-incubated dexamethasone and prednisolone.  Morassi A, Rivera-Vélez SM, Slovak JE, Court MH, Villarino NF.  J Vet Pharmacol Ther. 2018 Aug;41(4):513-521. PMID: 29687456.

Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.
Martinez MN, Court MH, Fink-Gremmels J, Mealey KL.   J Vet Pharmacol Ther. 2018 Aug;41(4):E57-E67. PMID:     29917248

Ex vivo binding of the immunosuppressant mycophenolic acid to dog and cat plasma proteins and the effect of co-incubated dexamethasone and prednisolone.
Morassi A, Rivera-Vélez SM, Slovak JE, Court MH, Villarino NF.   J Vet Pharmacol Ther. 2018 Aug;41(4):513-521. PMID:     29687456

Feline urine metabolomic signature: characterization of low-molecular-weight substances in urine from domestic cats.
Rivera-Vélez SM, Villarino NF.   J Feline Med Surg. 2018 Feb;20(2):155-163. PMID:     28367722

Safety of oral and intravenous mycophenolate mofetil in healthy cats.  Slovak JE, Villarino NF.  J Feline Med Surg. 2018 Feb;20(2):184-188. PMID:     28206810

Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis.  Dompreh A, Tang X, Zhou J, Yang H, Topletz A, Adu Ahwireng E, Antwi S, Enimil A, Langaee T, Peloquin CA, Court MH, Kwara A.  Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02099-17. PMID:   29263072


Simultaneous determination of mycophenolic acid and its glucuronide and glycoside derivatives in canine and feline plasma by UHPLC-UV. Rivera SM, Slovak JE, Court MH, Villarino NF. Biomed Chromatogr. 2017 Aug;31(8). doi: 10.1002/bmc.3942. Epub 2017 Feb 27. PMID: 28146301

Pharmacokinetics of mycophenolic acid after intravenous administration of mycophenolate mofetil to healthy cats. Slovak JE, Rivera SM, Hwang JK, Court MH, Villarino NF. J Vet Intern Med. 2017 Nov;31(6):1827-1832.  PMID: 28892209

Identification and validation of the microRNA response elements in the 3'-untranslated region of the UDP glucuronosyltransferase (UGT) 2B7 and 2B15 genes by a functional genomics approach. Papageorgiou I, Court MH. Biochem Pharmacol. 2017 Dec 15;146:199-213.  PMID: 28962835

Establishment of reference ranges and evaluation of in vitro concentration-dependent platelet inhibition by acetylsalicylic acid for multiple electrode impedance aggregometry in healthy dogs.
Haines JM, Lee PM, Hegedus RM, Hwang JK, Court MH.   J Vet Pharmacol Ther. 2017 Dec;40(6):618-628. PMID: 28387027

Pharmacokinetics of a sustained-release formulation of meloxicam after subcutaneous administration to Hispaniolan Amazon parrots (Amazona ventralis). Guzman DS, Court MH, Zhu Z, Summa N, Paul-Murphy JR. J Avian Med Surg. 2017 Sep;31(3):219-224. PMID: 28891702

Race, gender, and genetic polymorphism contribute to variability in acetaminophen pharmacokinetics, metabolism, and protein-adduct concentrations in healthy African-American and European-American volunteers. Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ.  J Pharmacol Exp Ther. 2017 Sep;362(3):431-440. PMID: 28663312

Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach. Papageorgiou I, Court MH. Biochem Pharmacol. 2017 Aug 1; 137:93-106. PMID: 28433553

Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma.  Lyngby JG, Court MH, Lee PM.  J Vet Cardiol. 2017 Aug;19(4):384-395. PMID: 28602635

Comparison of chemotherapeutic drug resistance in cells transfected with canine ABCG2 or feline ABCG2. Lewis RS, Fidel J, Dassanayake S, Court MH, Burke NS, Mealey KL. Vet Comp Oncol. 2017 Jun;15(2):411-420. PMID:26464002

Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes. Slovak JE, Mealey K, Court MH. J Vet Pharmacol Ther. 2017 Apr;40(2):123-129. PMID: 27301298

Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs.  Perez TE, Mealey KL, Burke NS, Grubb TL, Court MH, Greene SA.  Vet Anaesth Analg. 2017 Mar;44(2):370-374. PMID: 28214221

Pharmacokinetics of terbinafine in little brown myotis (Myotis lucifugus) infected with Pseudogymnoascus destructans. Court MH, Robbins AH, Whitford AM, Beck EV, Tseng FS, Reeder DM. Am J Vet Res. 2017 Jan;78(1):90-99. PMID: 28029293

Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms. Street CM, Zhu Z, Finel M, Court MH. Xenobiotica. 2017 Jan;47(1):1-10. PMID: 26999266

Establishment of a cell line for assessing drugs as canine P-glycoprotein substrates: proof of principle.  Mealey KL, Dassanayake S, Burke NS.  J Vet Pharmacol Ther. 2017 Oct;40(5):545-551. PMID: 28093773


Tramadol metabolism to O-desmethyl tramadol (M1) and N-desmethyl tramadol (M2) by dog liver microsomes: Species comparison and identification of responsible canine cytochrome P-450s (CYPs). Perez Jimenez TE, Mealey KL, Grubb TL, Greene SA, Court MH. Drug Metab Dispos. 2016 Oct 6; 44 (12) 1963-1972. PMID: 27758804

Development and validation of an ultrafast chromatographic method for quantification of the immunosuppressant mycophenolic acid in canine, feline and human plasma. Rivera Vélez SM., Morassi A., Court MH., Slovak JE, Villarino NF. J Pharm Biomed Anal. 2016 Aug 12;131:94-102

Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver. Papageorgiou I, Freytsis M, Court MH.  Biochem Pharmacol. 2016 Oct 1;117:78-87. PMID: 27531059

Soy isoflavone metabolism in cats compared with other species: urinary metabolite concentrations and glucuronidation by liver microsomes. Redmon JM, Shrestha B, Cerundolo R, Court MH. Xenobiotica. 2016 May;46(5):406-15

Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing. Gammal RS, Court MH, Haidar CE, Iwuchukwu OF, Gaur AH, Alvarellos M, Guillemette C, Lennox JL, Whirl-Carrillo M, Brummel SS, Ratain MJ, Klein TE, Schackman BR, Caudle KE, Haas DW; Clin Pharmacol Ther. 2016 Apr;99(4):363-9

Polymorphisms in the canine glucocorticoid receptor alpha gene (NR3C1α). Costa A, Sellon RK, Court M, Burke NS, Mealey KL. J Vet Pharmacol Ther. 2016 Feb;39(1):16-21


A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients.  Chen S, Laverdiere I, Tourancheau A, Jonker D, Couture F, Cecchin E, Villeneuve L, Harvey M, Court MH, Innocenti F, Toffoli G, Lévesque E, Guillemette C. Pharmacogenomics J. 2015 Dec;15(6):513-20

Identification of a nonsense mutation in feline ABCB1. Mealey KL, Burke NS.  J Vet Pharmacol Ther. 2015 Oct;38(5):429-33.

P-glycoprotein mediated drug interactions in animals and humans with cancer.  Mealey KL, Fidel J.  J Vet Intern Med 2015 Jan;29(1):1-6.


Tyrosine kinase inhibitors enhance ciprofloxacin-induced phototoxicity by inhibiting ABCG2.  Mealey KL, Dassanayake S, Burke NS.  Oncology 2014;87(6):364-70.

Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6. Court MH, Almutairi FE, Greenblatt DJ, Hazarika S, Sheng H, Klein K, Zanger UM, Bourgea J, Patten CJ, Kwara A.  Antimicrob Agents Chemother. 2014 Jul;58(7):4145-52.