PrIMe News

PrIMe News

  • WSU study aims to prevent adverse drug reactions in dogs

    WSU Insider
  • Personalized Medicine for Dogs

    American Kennel Club Canine Health Foundation
  • Congratulations to Dr. Katrina Mealey for receiving the 2019 Lloyd E. Davis Award.

    Congratulations to Dr. Katrina Mealey for receiving the 2019 Lloyd E. Davis Award. The Lloyd E. Davis Award is presented every other year at the American Academy of Veterinary Pharmacology and Therapeutics Biennial to recognize outstanding lifetime achievements in research, teaching and professional service in the field of veterinary pharmacology. This award honors the legacy of Lloyd E. Davis, his original research into comparative drug disposition and his significant contributions to the development of veterinary pharmacology and therapeutics as a discipline.

    She was also named as Distinguish Fellow of the American Academy of Veterinary Pharmacology and Therapeutics.
  • Martinez Wins Poster Awards at Prestigious National Pharmacology Conference

    Stephanie Martinez
    Dr. Stephanie Martinez with her first place ribbon and certificate for her poster, “Isoform-Dependent Effects of Cytochrome P450 Oxidoreductase Polymorphisms on Drug Metabolism by Cytochrome P450 Enzymes in Dogs.”

    Dr. Stephanie Martinez, a PrIMe postdoctoral researcher in Dr. Michael Court’s laboratory, received not one, but two awards for her poster presentation in April at the American Society for Pharmacology and Experimental Therapeutics (ASPET) at Experimental Biology 2019 in Orlando, FL. Competing against some of the top pharmacology postdoctoral scientists in the country, she took first place in the Dolores C. Shockley Postdoctoral Poster Competition and second place in the Drug Metabolism and Disposition Division Postdoctoral Poster Competition.

    Her poster, “Isoform-Dependent Effects of Cytochrome P450 Oxidoreductase Polymorphisms on Drug Metabolism by Cytochrome P450 Enzymes in Dogs,” detailed her American Kennel Club Canine Health Foundation-funded work to functionally characterize the effects of recently discovered P450 oxidoreductase polymorphisms in dogs on drug metabolism in vitro. Her findings may explain, in part, slower drug metabolism in some sighthound breeds of dog.

    “It was an honor to have our veterinary work recognized at a primarily human pharmacology-oriented conference and it was great to let the pharmacology world know that we’re doing fantastic research here in PrIMe at WSU CVM,” said Dr. Martinez. 

    In addition to receiving two poster awards, Dr. Martinez also earned a competitive travel award from ASPET to attend the conference and was invited to give a podium presentation expanding upon her poster presentation. She was also appointed to ASPET’s Mentoring and Career Development Committee, which focusses on providing career development and mentoring to young scientists and promotes diversity in pharmacology. 

    Congratulations, Dr. Martinez! 

    See all the poser winners here:

  • SOS: Saving Sighthounds from Anesthetic Drug Death

    Today's Breeder
  • PrIMe researchers featured in Today’s Breeder magazine

    Drs. Katrina Mealey, Michael Court and Stephanie Martinez are featured in Issue 98 of Today’s Breeder, a Nestlé Purina publication. The article, “SOS: Saving Sighthounds from Anesthetic Drug Death,” details the research efforts by Drs. Court and Martinez to address the genetic causes of adverse drug reactions to anesthetics as well as delayed postoperative bleeding in Greyhounds and related sighthounds. “MDR1 Gene Mutation in Herding Breeds Tied to Adverse Drug Reactions,” showcases Dr. Mealey’s groundbreaking discovery of the MDR1 gene mutation and development of the genotyping test that has saved the lives of countless affected dogs.

    For more information about the sighthound DNA samples that PrIMe researchers are collecting for their ongoing studies featured in Today’s Breeder, Sighthound DNA Samples .

  • AKC awards $172,765 to PrIMe researchers to advance sighthound genetic research

    AKC Canine Health Foundation
  • PrIMe postdoctoral research associate wins first place at College of Veterinary Medicine Research Symposium

    Dr. Stephanie Martinez, a PrIMe postdoctoral research associate in Dr. Michael Court’s laboratory took first place for her poster presentation, “Effects of Canine Cytochrome P450 Oxidoreductase Polymorphisms on P450-Mediated Drug Metabolism,” at the Washington State University College of Veterinary Medicine Student and Post-Doctoral Research Symposium in the post-doctoral category on October 25, 2018. The Symposium is an annual event for College of Veterinary Medicine students and post-doctoral trainees to present their research to the University community. PrIMe was also well-represented at the Symposium by postdoctoral research associate, Dr. Sol Rivera, and PhD student, Dr. Ana Costa. Dr. Rivera presented her work on feline metabolomics and Dr. Costa presented her research on the effects of plasma protein variants on drug-protein binding interactions in dogs. 

  • AKC Canine Health Foundation awards PrIMe graduate student Clinical-Scientist Fellowship

    AKC Canine Health Foundation
  • 2018 Woman of Distinction: Saving animal lives every day

    2018 Woman of Distinction: Saving animal lives every day

    Katrina Mealey is the Richard L. Ott Endowed Chair in Small Animal Medicine and Research at WSU, the founding director of PrIMe (Program in Individualized Medicine for animals), a National Academy of Inventors member, and global expert in veterinary pharmacogenetics.  WSU Insider
  • PrIMe researcher receives AKC Canine Health Foundation grant to study adverse drug effects in diabetic dogs.

    The American Kennel Club (AKC) Canine Health Foundation has awarded $14,435 to Dr. Nicolas Villarino to study adverse drug reactions in diabetic dogs.  The project entitled “Development of an in vitro model for individualization of pharmacological interventions in diabetic dogs”  will study how the effects of hyperglycemia-induced metabolic changes affect drug disposition.  In human diabetic patients, hyperglycemia induced metabolic changes are known to increase the risk of adverse drug reactions.  The long term goal of this line of research is to enable veterinarians to optimize drug doses in diabetic dogs in order to avoid adverse drug reactions.

    Source: AKC Canine Health Foundation
  • WSU Honors College student wins SURCA award for individualized medicine research

    Marie AndresenMarie Andresen, a WSU Honors College student mentored by PrIMe researcher Dr Michael Court, won a Novice Researcher Award for her presentation on “Pharmacogenomics of Propofol Metabolism by Cytochrome P450 Enzymes in Dogs.” at the SURCA poster event on March 27th 2017.  SURCA is the Showcase for Undergraduate Research and Creative Activities that is held each year to provide a venue for students to disseminate the results of their research, scholarship, and creative activities.  The work presented by Marie is part of her honors thesis project with her final defense scheduled for April 13th 2017.  Marie has been accepted into the 7-year DVM track through the Honors College and will begin her veterinary training in the fall of 2018.

  • WSU veterinary professor named fellow of National Academy of Inventors

    Washington State University professor Katrina L. Mealey has been elected a fellow of the National Academy of Inventors - a prestigious group of scientists that includes 27 Nobel laureates. Read More
  • PrIMe graduate student identifies gene essential for effective pain treatment in dogs

    Tramadol is one of the most widely prescribed drugs for treatment of mild to moderate pain in dogs.  However, there is growing evidence that this drug may not work well in some patients because of genetic differences.  Dr. Tania E. Perez-Jimenez (DVM, MS), a graduate student in Dr. Michael Court’s Pharmacogenomics laboratory, has identified a gene that is essential for “turning on” the pain relieving effects of tramadol in dogs.  The gene called CYP2D15 produces an enzyme that converts tramadol into M1.  Tramadol by itself lacks any pain relieving effects and must first be converted into M1 in the liver before it can alleviate pain.  A related gene in humans (CYP2D6) produces a similar enzyme that is essential for forming M1 from tramadol in people.  However, tramadol is ineffective for treating pain in 5 to 10% of people because they have a mutation in CYP2D6 and do not produce sufficient amounts of M1.  Consequently, the next step in the project is to determine whether there are mutations in the canine CYP2D15 gene that could also explain why some dogs do not achieve adequate pain relief from tramadol.   Dr. Perez’s discoveries were recently reported in the journal Drug Metabolism and Disposition (PMID: 27758804), and were funded by a Morris Animal Foundation Training Fellowship and the William R. Jones Endowment at WSU. Read More
  • PrIMe research team develops assay for immunosuppressant drug to improve its safe use in dogs and cats

    Mycophenolic acid (MPA) is the active metabolite of the immunosuppressant prodrug mycophenolate mofetil. In this study, we developed and validated a novel ultra-high performance liquid chromatography (UHPLC) method for the rapid quantification of MPA in plasma from dogs, cats and humans. The advantages of this method include: high sensitivity and reproducibility over a wide range of MPA plasma concentrations, small sample volume and easy sample preparation. By combining isocratic conditions with a UHPLC column containing solid core particles, we were able to elute MPA within 3.0 min. The very short chromatographic analysis time makes this method ideal to study the disposition of MPA in large batches of plasma samples and/or monitor plasma drug concentrations, as recommended for patients that require optimized immunosuppression. Read More
  • PrIMe researcher receives grant to improve safety of pain medications for cats

    Cats are the most common pet in the United States. Every year, thousands of cats unnecessarily suffer from pain and inflammation when they could have benefitted from treatment with non-steroidal anti-inflammatory drugs (NSAIDs) such as meloxicam.  This is because relative to most dogs and humans, cats are more likely to experience serious side effects from NSAIDs, limiting safe and effective inflammation and pain control in this species. Understanding the effects of NSAIDs on cellular metabolism in cats will help unveil the mechanism underlying their predisposition to serious side effects relative to other species and open the way to substantial advances in the treatment of inflammation and pain in these animals. In this study we will determine the effects of chronic meloxicam administration on cellular metabolite profiles in cat plasma and urine. We will apply an untargeted metabolomics approach that will allow us to identify currently unknown metabolite changes that could explain why cats are predisposed to adverse effects of the NSAID meloxicam.
  • AKC awards $150,000 to PrIMe laboratory for Sighthound genetic research

    The American Kennel Club (AKC) has awarded $150,000 to Dr. Michael H. Court BVSc, PhD (principal investigator) and Dr. Stephanie Martinez, PhD. (postdoctoral fellow) to study adverse drug reactions in greyhounds and related sighthound dog breeds.   The project entitled “Understanding the Genetics of Adverse Drug Reactions in Sighthounds” (AKC grant #02242) will determine the effect of several genetic mutations on drug metabolism enzyme function using cell-based model systems.  These mutations were discovered in a targeted genetic screen of greyhound DNA and may explain why some greyhounds wake up slowly from a number of anesthetic drugs.  Importantly, other sighthound dog breeds such as Scottish deerhounds and non-sighthound breeds such as border collies have this mutation.  The ultimate goal is to develop a genetic test that could identify dogs at risk that will require different drugs or drug dosages. AKC Canine Health Foundation
  • Genetic variant of drug transporter gene in cats predisposes to drug toxicity

    A research team in the Program in Individualized Medicine identified a mutation in a gene encoding a drug transporter that is a key component of the blood brain barrier.  The Animal Poison Control Center contacted Dr. Katrina Mealey when a cat that experienced neurological toxicity after being treated for ear mites.  Using DNA from that cat, a 2 base pair deletion was identified in the ABCB1 gene (ABCB11930_1931del TC) .  Mealey and her team then sequenced the gene in 100 other cats from the WSU College of Veterinary Medicine’s DNA Bank and found that approximately 4% of cats have the genetic defect.  By knowing which cats have the genetic defect prior to treatment for ear mites (and other diseases), veterinarians can use alternative treatments and prevent adverse drug reactions in cats. Read More
  • PrIMe graduate student awarded Morris Animal Foundation Fellowship

    Dr. Tania E. Perez-Jimenez (DVM, MS) has been awarded a highly competitive 2-year Fellowship training grant from the Morris Animal Foundation in support of her PhD thesis project.  Dr. Perez recently completed her training as a veterinary anesthesiologist in the WSU residency program under Drs. Tammy Grubb and Stephen Greene (PriMe faculty members); and is now receiving pharmacology research training in Dr. Michael Court’s Pharmacogenomics laboratory.  The goal of her study is to improve the effectiveness of tramadol for pain relief in dogs through genetic testing and combination drug therapies.  Although tramadol is widely used by veterinarians to treat mild to moderate pain in dogs, there is evidence that this drug may not work well in many patients because of genetic differences and administration of other interacting drugs.  Her study will identify genes (and ultimately a gene test) that could be used to determine which dogs would respond best to tramadol.  She will also identify which other drugs could interfere with the analgesic effect of tramadol (and should be avoided), and also which other drugs might boost the pain relief from tramadol (and could be given as a combination therapy). Morris Animal Foundation
  • Launch of the WSU Program in Individualized Medicine

    Carlee, a 7-year-old yellow lab, is a mutant. Like many of her human redheaded counterparts, Carlee has a mutation in the MC1-R gene, or melanocortin 1 receptor. The gene is responsible for producing melanin, a pigment that determines hair, or in this case, coat color. Because humans with red hair often have a lower threshold for thermal pain, researchers at the WSU College of Veterinary Medicine wondered if they would find similar results in ... Read More