Michael H. Court

Michael H. Court,

B.V.Sc., Ph.D.

Professor and William R. Jones Endowed Chair
Department of Veterinary Clinical Sciences
Diplomate, American College of Veterinary Anesthesiologists

Email: michael.court@wsu.edu
Office: ADBF
Phone: 509-335-0817

Education

Queensland University, BVSc Hons., 1981
University of Sydney, Internship, Small Animal, 1982
Tufts University, Residency, Anesthesia, 1985
Flinders University, Fellowship, Pharmacology, 1999
Tufts University, PhD, Pharmacology and Experimental Therapeutics 2000

Dr. Michael Court

Active Call for DNA Samples

We are currently seeking DNA samples from sighthounds who may have experienced either delayed postoperative bleeding  or an adverse reaction to an anesthesia or sedative drug that caused unexpected slow recovery or increased body temperature (malignant hyperthermia).  More information including contact email is provided in the following flier:

WSU Sighthound Genetics Study Advertisement - 11-2-2018

Research Interests

My laboratory primarily conducts pharmacogenomic research, including studies designed to identify genetic variants and related mechanisms that determine interindividual differences in drug effect (both beneficial and adverse).  The long-term goal of our work is to translate these findings into clinical practice and improve the treatment of important diseases through pharmacogenomic-guided selection of the most effective and safest drug and drug dose for the individual patient (individualized therapeutics).  One of the main projects in our laboratory is attempting to understand the molecular and genetic basis for increased sensitivity of some sighthound dog breeds (such as greyhounds) to certain injectable anesthetic agents.  We are also trying to find the genetic cause of several other sighthound problems, including hyperfibrinolysis causing delayed postoperative bleeding and stress/anesthesia induced hyperthermia.  The ultimate goal of this work is to develop predictive genetic and phenotypic tests to identify dogs at risk. 

Publications

  • Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization.  Martinez SE, Andresen MC, Zhu Z, Papageorgiou I, Court MH. Sci Rep. 2020 Jan 9;10(1):69. PMID: 31919457.

  • Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability.  Martinez SE, Shi J, Zhu HJ, Perez Jimenez TE, Zhu Z, Court MH.  Drug Metab Dispos. 2019 Nov;47(11):1314-1324. PMID: 31427433

  • Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding.  Costa AP, Court MH, Burke NS, Zhu Z, Mealey KL, Villarino NF.  Drug Metab Dispos. 2019 Oct;47(10):1024-1031. PMID: 31481400

  • Comparison of metabolomics and platelet aggregometry between Plavix and generic clopidogrel in cats: a pilot study.Malkawi M, Woolcock AD, Lee PM, Court MH, Moore GE, Hogan DF.  J Feline Med Surg. 2019 Oct;21(10):951-958. PMID: 30427274.

  • Comparison of metabolomics and platelet aggregometry between Plavix and generic clopidogrel in cats: a pilot study.Malkawi M, Woolcock AD, Lee PM, Court MH, Moore GE, Hogan DF.  J Feline Med Surg. 2019 Oct;21(10):951-958. PMID: 30427274.

  • Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.  Enimil A, Antwi S, Yang H, Dompreh A, Alghamdi WA, Gillani FS, Orstin A, Bosomtwe D, Opoku T, Norman J, Wiesner L, Langaee T, Peloquin CA, Court MH, Greenblatt DJ, Kwara A.  Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00839-19. PMID: 31332062

  • Personalized medicine: going to the dogs?  Mealey KL, Martinez SE, Villarino NF, Court MH. Hum Genet. 2019 May;138(5):467-481. PMID: 31032534

  • Investigation into the causes of aspirin resistance in healthy dogs. Haines JM, Lee PM, Hegedus RM, Hwang JK, Court MH. J Vet Pharmacol Ther. 2019 Mar;42(2):160-170. PMID: 30302763.

  • Genomes of Three Closely Related Caribbean Amazons Provide Insight for Species History and Conservation. Kolchanova S, Kliver S, Komissarov A, Dobrinin P, Tamazian G, Grigorev K, Wolfsberger WW, Majeske AJ, Velez-Valentin J, Valentin de la Rosa R, Paul-Murphy JR, Guzman DS, Court MH, Rodriguez-Flores JL, Martínez-Cruzado JC, Oleksyk TK. Genes (Basel). 2019 Jan 16;10(1). pii: E54. PMID: 30654561.

  • Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs. Perez Jimenez TE, Kukanich B, Joo H, Mealey KL, Grubb TL, Greene SA, Court MH. Drug Metab Dispos. 2019 Jan;47(1):15-25. PMID: 30366901.

  • High interindividual variability in plasma clopidogrel active metabolite concentrations in healthy cats is associated with sex and cytochrome P450 2C genetic polymorphism.
    Lee PM, Faus MCL, Court MH.  J Vet Pharmacol Ther. 2019 Jan;42(1):16-25. PMID: 30251376.

  • Effect of Rifampin-Isoniazid-Containing Antituberculosis Therapy on Efavirenz Pharmacokinetics in HIV-Infected Children 3 to 14 Years Old. Kwara A, Yang H, Antwi S, Enimil A, Gillani FS, Dompreh A, Ortsin A, Opoku T, Bosomtwe D, Sarfo A, Wiesner L, Norman J, Alghamdi WA, Langaee T, Peloquin CA, Court MH, Greenblatt DJ. Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01657-18. PMID: 30397066.

  • Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes.  Perez Jimenez TE, Mealey KL, Schnider D, Grubb TL, Greene SA, Court MH. J Vet Pharmacol Ther. 2018 Dec;41(6):815-824. PMID: 30113702.

  • Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.
    Martinez MN, Court MH, Fink-Gremmels J, Mealey KL.   J Vet Pharmacol Ther. 2018 Aug;41(4):E57-E67. PMID:     29917248

  • Ex vivo binding of the immunosuppressant mycophenolic acid to dog and cat plasma proteins and the effect of co-incubated dexamethasone and prednisolone.
    Morassi A, Rivera-Vélez SM, Slovak JE, Court MH, Villarino NF.   J Vet Pharmacol Ther. 2018 Aug;41(4):513-521. PMID:  29687456

  • Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis.  Dompreh A, Tang X, Zhou J, Yang H, Topletz A, Adu Ahwireng E, Antwi S, Enimil A, Langaee T, Peloquin CA, Court MH, Kwara A.  Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02099-17. PMID:   29263072

  • Simultaneous determination of mycophenolic acid and its glucuronide and glycoside derivatives in canine and feline plasma by UHPLC-UV. Rivera SM, Slovak JE, Court MH, Villarino NF. Biomed Chromatogr. 2017 Aug;31(8). doi: 10.1002/bmc.3942. Epub 2017 Feb 27. PMID: 28146301

  • Pharmacokinetics of mycophenolic acid after intravenous administration of mycophenolate mofetil to healthy cats. Slovak JE, Rivera SM, Hwang JK, Court MH, Villarino NF. J Vet Intern Med. 2017 Nov;31(6):1827-1832.  PMID: 28892209

  • Identification and validation of the microRNA response elements in the 3'-untranslated region of the UDP glucuronosyltransferase (UGT) 2B7 and 2B15 genes by a functional genomics approach. Papageorgiou I, Court MH. Biochem Pharmacol. 2017 Dec 15;146:199-213.  PMID: 28962835

  • Establishment of reference ranges and evaluation of in vitro concentration-dependent platelet inhibition by acetylsalicylic acid for multiple electrode impedance aggregometry in healthy dogs. Haines JM, Lee PM, Hegedus RM, Hwang JK, Court MH.   J Vet Pharmacol Ther. 2017 Dec;40(6):618-628. PMID: 28387027

  • Pharmacokinetics of a sustained-release formulation of meloxicam after subcutaneous administration to Hispaniolan Amazon parrots (Amazona ventralis). Guzman DS, Court MH, Zhu Z, Summa N, Paul-Murphy JR. J Avian Med Surg. 2017 Sep;31(3):219-224. PMID: 28891702

  • Race, gender, and genetic polymorphism contribute to variability in acetaminophen pharmacokinetics, metabolism, and protein-adduct concentrations in healthy African-American and European-American volunteers. Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ.  J Pharmacol Exp Ther. 2017 Sep;362(3):431-440. PMID: 28663312

  • Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach. Papageorgiou I, Court MH. Biochem Pharmacol. 2017 Aug 1; 137:93-106. PMID: 28433553

  • Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma.  Lyngby JG, Court MH, Lee PM.  J Vet Cardiol. 2017 Aug;19(4):384-395. PMID: 28602635

  • Comparison of chemotherapeutic drug resistance in cells transfected with canine ABCG2 or feline ABCG2. Lewis RS, Fidel J, Dassanayake S, Court MH, Burke NS, Mealey KL. Vet Comp Oncol. 2017 Jun;15(2):411-420. PMID:26464002

  • Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes. Slovak JE, Mealey K, Court MH. J Vet Pharmacol Ther. 2017 Apr;40(2):123-129. PMID: 27301298

  • Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs.  Perez TE, Mealey KL, Burke NS, Grubb TL, Court MH, Greene SA.  Vet Anaesth Analg. 2017 Mar;44(2):370-374. PMID: 28214221

  • Pharmacokinetics of terbinafine in little brown myotis (Myotis lucifugus) infected with Pseudogymnoascus destructans. Court MH, Robbins AH, Whitford AM, Beck EV, Tseng FS, Reeder DM. Am J Vet Res. 2017 Jan;78(1):90-99. PMID: 28029293

  • Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms. Street CM, Zhu Z, Finel M, Court MH. Xenobiotica. 2017 Jan;47(1):1-10. PMID: 26999266

  • Development and validation of an ultrafast chromatographic method for quantification of the immunosuppressant mycophenolic acid in canine, feline and human plasma.Rivera Vélez SM, Morassi A, Court MH, Slovak JE, Villarino NF.  J Pharm Biomed Anal. 2016 Nov 30;131:94-102. PMID: 27552122.

  • Tramadol metabolism to O-desmethyl tramadol (M1) and N-desmethyl tramadol (M2) by dog liver microsomes: Species comparison and identification of responsible canine cytochrome P-450s (CYPs). Perez Jimenez TE, Mealey KL, Grubb TL, Greene SA, Court MH. Drug Metab Dispos. 2016 Oct 6; 44 (12) 1963-1972. PMID: 27758804

  • Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver. Papageorgiou I, Freytsis M, Court MH.  Biochem Pharmacol. 2016 Oct 1;117:78-87. PMID: 27531059

  • Soy isoflavone metabolism in cats compared with other species: urinary metabolite concentrations and glucuronidation by liver microsomes. Redmon JM, Shrestha B, Cerundolo R, Court MH. Xenobiotica. 2016 May;46(5):406-15

  • Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing. Gammal RS, Court MH, Haidar CE, Iwuchukwu OF, Gaur AH, Alvarellos M, Guillemette C, Lennox JL, Whirl-Carrillo M, Brummel SS, Ratain MJ, Klein TE, Schackman BR, Caudle KE, Haas DW; Clin Pharmacol Ther. 2016 Apr;99(4):363-9

  • Polymorphisms in the canine glucocorticoid receptor alpha gene (NR3C1α). Costa A, Sellon RK, Court M, Burke NS, Mealey KL. J Vet Pharmacol Ther. 2016 Feb;39(1):16-21

  • A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients.  Chen S, Laverdiere I, Tourancheau A, Jonker D, Couture F, Cecchin E, Villeneuve L, Harvey M, Court MH, Innocenti F, Toffoli G, Lévesque E, Guillemette C. Pharmacogenomics J. 2015 Dec;15(6):513-20

  • Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6. Court MH, Almutairi FE, Greenblatt DJ, Hazarika S, Sheng H, Klein K, Zanger UM, Bourgea J, Patten CJ, Kwara A.  Antimicrob Agents Chemother. 2014 Jul;58(7):4145-52.