If you know whether the sire and dam have the mutant MDR1 gene, you can accurately predict if puppies in their litter will have the MDR1 genetic mutation.
The chart below details breeding pair combinations and outcomes:
|Normal/Normal Male||Normal/Mutant* Male||Mutant/Mutant Male|
|Normal/Normal Female||100% Normal/Normal puppies||Normal/Normal and/or Normal/Mutant puppies||100% Normal/Mutant puppies|
|Normal/Mutant* Female||Normal/Normal and/or Normal Mutant puppies||Any combination of puppies||Normal/Mutant and/or Mutant/Mutant puppies|
|Mutant/Mutant Female||100% Normal/Mutant puppies||Normal/Mutant and/or Mutant/Mutant puppies||100% Mutant/Mutant puppies|